Inclusion Criteria
Eligible patients are adults, aged 75 years or under who:
 1. Have had a cutaneous melanoma with a Breslow thickness 0.75mm or thicker excised, and who also have had a positive sentinel node biopsy result or nodal involvement from melanoma.
2. Have given informed consent and have initialed all parts of the consent form.
Patients below 18 years of age are eligible if their legal representatives have given informed consent and have initialled all parts of the consent form.
For patients who are taking part in EORTC trials 18071 & 18041, the inclusion criteria for this study remains the same as for that particular trial.
Exclusion Criteria
Ineligible patients include those who:
1. Have a primary melanoma that has not originated in the skin.
2. Have previously suffered or concurrently suffer from another malignancy (other than non-melanoma skin cancer or cervical carcinoma in situ).
3. Patients that have had multiple malignant melanomas with dermal invasion.
4. Are unable to provide informed consent.
NB: Patients can still participate even if they wish to consent to only specific parts of the consent form.
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