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Access to the Members' Section is restricted to people who work for our parent organisations or who belong to one of our Groups, such as the Scientific Advisory Board. If you fall into one of these categories please email info@genomel.org to obtain access.

Welcome to GenoMEL

We are a world leader in familial melanoma research. Our website contains a wealth of information about our research consortium and includes interactive materials for medical professionals, melanoma patients and their families, and the general public.

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GenoMEL is an international research consortium coordinated by the University of Leeds
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GenoMEL is an FP6 project and as such is funded by the European Commission
National Institute of Health logo
GenoMEL also receives substantial support from the National Cancer Institute (NCI) of the US National Institutes of Health (NIH) (CA83115).

JUNE NEWS

Prof. Julia Newton Bishop speaking at a recent public event


New Fellow of the Academy of Medical Sciences
The consortium's coordinator, Prof. Julia Newton Bishop, has been elected to the Fellowship of the Academy of Medical Sciences. Academy Fellows are elected for excellence in medical research, innovative application of scientific knowledge or conspicuous service to healthcare. This prestigious award is recognition of Julia's contribution to understanding melanoma genetics.
Congratulations!

Posted on 18 June 2014 | 11:12 am by The Editor

BioGenoMEL

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MAY NEWS


Researchers at the 2014 meeting

2014 meeting

Over 60 researchers attended the joint GenoMEL/BioGenoMEL meeting in Valencia earlier this month. There were over 40 scientific presentations of world leading research with additional participation over the Internet. Such e-participation was been trialled at this event and is likely to feature again in future meetings. Our thanks go to Dr. Eduardo Nagore and the Fundacion Instituto Valenciano de Oncologia for hosting the meeting. 


The Swedish flag
2015 meeting
The next annual meeting will be in Lund, Sweden!

Posted on 13 May 2014 | 10:54 am by The Editor

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APRIL NEWS

The sun
Knowing your skin
GenoMEL's coordinator, Prof. Julia Newton Bishop, is involved in an exciting new project investigating our relationship with the sun via embroidery. To find out more about this novel development please visit the project website here.

Posted on 30 April 2014 | 6:27 pm by The Editor

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FEBRUARY NEWS

Flag of Spain


The 2014 meeting
The joint GenoMEL/BioGenoMEL meeting will be in Valencia, Spain 7-9 May. If you have any meeting queries please get in touch - info@genomel.org

Posted on 25 February 2014 | 5:17 pm by The Editor

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DECEMBER NEWS

International Racehorse Transport
Christmas Donation
As part of their annual Christmas message to clients, IRT sends a newsletter highlighting a worthy cause. This Christmas IRT highlighted skin cancer and their UK office choose to support GenoMEL. IRT is the leading international horse transport company with its global headquarters in Australia and so skin awareness is a particularly relevant issue. We are very grateful for their donation of £1,500.

Posted on 6 January 2014 | 11:40 am by The Editor

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NOVEMBER NEWS

Rachel Barber with her Great North Run medal
Fund raising success
Rachel Barber recently completed the Great North Run and asked for sponsorship in memory of her dear friend Jenny, who she lost to melanoma. Rachel has raised over £500 to support GenoMEL's research. Donations are still being accepted at JustGiving.com Congratulations to Rachel and thank you to all her sponsors.

Posted on 26 November 2013 | 11:26 am by The Editor

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SEPTEMBER NEWS




Geoff Walker completing 'Ironman France'

Fund raising success
Geoff Walker recently completed Ironman France and asked for sponsorship in memory of a dear friend, Bernie Jackson, who died from melanoma earlier this year. The challenge involved over 140 miles of swimming, biking and running and Geoff has raised over £2,000 to support GenoMEL's research. Donations are still being accepted at  JustGiving.com Congratulations to Geoff and thank you to all his sponsors.

Dr. Jim Olson's TEDxSeattle talk
We've been contacted by Dr. Jim Olson to publicise his Project Violet initiative. This is an exciting and novel project to raise funds for cancer research. To find out more visit the project violet website and watch his inspirational TEDx talk (the Washington Research Foundation has offered to donate $10 for each viewing of his talk).




Posted on 21 August 2013 | 1:46 pm by The Editor

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AUGUST NEWS




New GenoMEL paper in the Journal of Investigative Dermatology
A GenoMEL study of somatic BRAF and NRAS mutations in familial melanomas with known germline CDKN2A status has been published in the Journal of Investigative Dermatology. This study set out to investigate whether inheriting a CDKN2A mutation influences the mutations found within the actual tumour. Led by researchers in Sweden, it involved colleagues from more than eight different research groups and samples from over 100 patients.

Posted on 2 August 2013 | 5:21 pm by The Editor

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JULY NEWS


Flag of the Land of Valencia

 GenoMEL annual meetings
The 2013 meeting in Philadelphia was a great success. As well as pleasing progress with existing projects, several new initiatives and grant awards were announced.  The meeting also featured GenoMEL's first remote presentation, with Dr Nadine Kasparian presenting from Sydney, Australia 9,000 miles away. We are very grateful to the Abramson Cancer Center and the Center for Clinical Epidemiology and Biostatistics at the University of Pennsylvania for their support.
Dr. Eduardo Nagore from the Valencia Institute of Oncology has kindly offered to host the 2014 meeting in Valencia, Spain. Dates to be announced!

Posted on 9 July 2013 | 6:05 pm by The Editor

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MAY NEWS


Flag of the United States

 Annual GenoMEL meeting, 26-28 June, 2013
The 2013 meeting in Philadelphia, the City of Brotherly Love, is rapidly approaching. For more information please contact info@genomel.org

Posted on 7 May 2013 | 4:22 pm by The Editor

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MARCH NEWS

World spanning research*
New Nature Genetics paper
A new GenoMEL paper is available from the Nature Genetics website entitled, 'A variant in FTO shows association with melanoma risk not due to BMI'. Some variations in the FTO gene have been linked to obesity, but this is the first study to link FTO variations with melanoma. This was a global study of more than 13,000 melanoma patients and a huge collaborative effort.
A University of Leeds press release is available.


*Image courtesy of posterize at FreeDigitalPhotos.net

Posted on 5 March 2013 | 3:24 pm by The Editor

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FEBRUARY NEWS

The CDK4 protein

New CDK4 paper
A new Journal of Medical Genetics paper from GenoMEL is available online. It reports an international study of all known families with rare germline mutations in the CDK4 gene, led by Professor Anders Molven from the University of Bergen in Norway. This open access paper is an impressive achievement, involving numerous collaborators. It is available from the journal's website.

Posted on 12 February 2013 | 12:06 pm by The Editor

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JANUARY NEWS

Award for New Knowledge Directorate
An initiative of one of GenoMEL's SME members, NKD, has been awarded a Runner Up place in the 2012 Medilink Healthcare Business Awards. This initiative, called Osmosis, uses cloud computing to help doctors keep track of their online research and learning. This can be crucial to annual appraisals and revalidation. For more information please email osmosis@osmosis.me

info@genomel.org

Posted on 7 January 2013 | 5:16 pm by The Editor

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DECEMBER NEWS

Dace Pjanova, Kristine Azerjana and Wilma Bergman

News from Latvia
Congratulations to GenoMEL member Kristine Azerjana! Kristine successfully defended her thesis on the 12 November, in Riga, Latvia. She is pictured with her promoter, Dr. Dace Pjanova and her invited opposer, Prof. Wilma Bergman.

Website update
The GenoMEL website's privacy policy has been updated to better explain our use of Google Analytics to monitor visitor numbers. Google Analytics works by placing a 'cookie' on the user's computer so that it can tell the difference between a first time visitor and a returning visitor. The policy now gives details of how to opt out of Google Analytics.


Posted on 4 December 2012 | 2:57 pm by The Editor

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OCTOBER NEWS

A different sort of cookie*



Website privacy policy
The GenoMEL website's privacy policy has been updated to better explain our use of Google Analytics to monitor visitor numbers and usage. Google Analytics works by placing a 'cookie' on the user's computer so that it can tell the difference between a first time visitor and a returning visitor. The policy now gives details of how to opt out of Google Analytics.

*Image courtesy of Paul/FreeDigitalPhotos.net

Posted on 24 September 2012 | 1:36 pm by The Editor

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SEPTEMBER NEWS

Flag of the United States

The 2013 GenoMEL meeting
 We are happy to announce that next year's GenoMEL meeting will be in Philadelphia, the City of Brotherly Love, 26-28 June.

New GenoMEL paper
A fourth paper has been published based on GenoMEL's health psychology studies. It highlights the need for more effective communication of genetic test results. To find out more please visit the European Journal of Cancer website. Congratulations to all involved.


info@genomel.org


Posted on 21 August 2012 | 11:59 am by The Editor

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AUGUST NEWS

JFK Plaza in Philadelphia


Location of the 2013 GenoMEL meeting
Our next annual meeting will be in the city of Philadelphia. This will be GenoMEL's first annual meeting in the USA since 2004. The meeting will be in June or July - the precise dates will be announced soon.

New GenoMEL paper
GenoMEL's latest paper is now available online. It reports further findings from GenoMEL's health psychology questionnaires. To find the article please visit the website of the journal Archives of Dermatology.

Posted on 25 July 2012 | 11:02 am by The Editor

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JULY NEWS


2012 GenoMEL meeting
Over 50 people from 10 different countries attended the recent meeting at Leiden University Medical Center in the Netherlands. There were over 40 talks including two from eminent invited guest speakers. The meeting demonstrated the continuing commitment of GenoMEL members.


Posted on 28 June 2012 | 1:48 pm by The Editor

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JUNE NEWS

The Dutch flag
Annual GenoMEL meeting
The annual meeting is taking place in Leiden, the Netherlands 18-20 June. If you have any attendance queries please email info@genomel.org

Posted on 11 June 2012 | 3:05 pm by The Editor

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MAY NEWS


 
Advances in the genetics of melanoma lecture
The leader of GenoMEL's INSERM group, Dr. Florence Demenais, recently gave a lecture entitled, New advances in the genetics of melanoma: how can it contribute to personalized medicine? The lecture can be viewed online at the videolectures.net website.

info@genomel.org




Posted on 30 April 2012 | 4:27 pm by The Editor

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MARCH NEWS


Skin Cancer Exposed
XploreHealth, a scientific 'portal' financed by the European Union, has produced a module concerning melanoma. The 'Skin Cancer Exposed' module features interviews with GenoMEL members and seeks to engage citizens, patients, schoolchildren and teachers.


info@genomel.org

Posted on 26 March 2012 | 1:39 pm by The Editor

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FEBRUARY NEWS



2012 annual meeting
The 2012 meeting will take place in Leiden, the Netherlands 18-20 June. The meeting is open to GenoMEL members and invited guests. The registration page is now available.

The hunt for high and low risk melanoma genes
Dr. Peter Kanetsky, from GenoMEL's group in Pennsylvania, gave a talk late last year to students, researchers and clinicians at the University of Wisconsin about GenoMEL's genetic research. The talk is available as a webcast.

Posted on 2 February 2012 | 12:09 pm by The Editor

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JANUARY NEWS



New GenoMEL paper
A paper entitled 'Pathway-based analysis of a melanoma genome-wide association study: analysis of genes related to tumour-immunosuppression' has been published in PLoS ONE and is available online. Congratulations to all involved.

Dissemination case study
GenoMEL has written a short case study on how to disseminate project results via the web. For more information please visit our knowledge transfer page.

2012 Meeting
The 2012 GenoMEL meeting will be in Leiden, 18-20 June. The registration page is available here.

info@genomel.org

Posted on 5 January 2012 | 11:42 am by The Editor

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DECEMBER NEWS



Dissemination case study
As part of the final FP6 NoE report, GenoMEL has written a short case study on how to disseminate project results via the web. To access the case study please visit our knowledge transfer page.

Nature paper
Two of GenoMEL's French groups, led by Brigitte Bressac and Florence Demenais, have recently published an article in the journal Nature entitled, 'A SUMOylation-defective MITF mutation predisposes to melanoma and renal carcinoma.'


info@genomel.org

Posted on 1 December 2011 | 12:27 pm by The Editor

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NOVEMBER NEWS



New Nature Genetics paper
GenoMEL has a new Nature Genetics paper entitled, 'Genome-wide association study identifies three new melanoma susceptibility loci'. A press release is available here. This paper represents a great deal of effort from numerous GenoMEL members - congratulations to everyone involved.

info@genomel.org

Posted on 31 October 2011 | 10:56 am by The Editor

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Site and presentations created by NKD Ltd

Glossary

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Associated
When two things are associated they are connected or joined in some way. It may be that one thing causes the other but they could be linked in some other way. For instance, if both things were caused by a separate, third thing.
Clinical geneticist
A doctor concerned with the care of people with genetic conditions.
Dermatologist
A specialist 'skin' doctor.
Freckle
A small brown patch on the skin that becomes darker following exposure to sunlight. Freckles can vary from light brown to dark brown, and are often found on the cheeks and across the bridge of the nose.
Genes
Genes are pieces of genetic 'code': they are the instructions or recipes that our bodies use for growth and repair.
GenoMEL
The Melanoma Genetics Consortium: an international, collaborative organisation researching the genetics of melanoma.
High-risk genes
Particular genes can make us more susceptible to diseases. If we have changes in them called mutations, and if the mutation significantly increase the risk of a disease (as compared to someone who does not have a mutation in the gene), it is called a high-risk gene.
IU
International Units
Melanoma
Melanoma is a form of cancer that develops from the pigment producing cells of the skin. If untreated it can spread through the body and is potentially fatal.
Microgram
A microgram (mcg) is a millionth of a gram.
Mutations
Mutations are changes or faults in our genes. Sometimes mutations can increase our chances of developing a disease.
nmol/L
nmol/L stands for nanomoles per litre. A nanomole is an extremely small unit of measurement.
Nervous system tumours
The nervous system consists of the brain, spinal cord, nerves and other structures that control our bodies. A tumour is an abnormal growth, which can be cancerous (having the potential to spread around the body) or benign (the growth remains in a single spot but may continue to grow in size).
Pancreas
The pancreas is a gland that lies behind the stomach. It produces digestive juices and controls blood sugar levels.
Risk
We are using the word risk to mean the chances of something happening. For example, if something is more likely to happen to John than to Peter then John is at greater risk than Peter.
SPF
Sun Protection Factor
UVA
UVA is a form of ultraviolet radiation. It is sometimes called long wave UV or black light.
Uveal melanoma
Uveal melanoma is a melanoma that occurs either in the coloured part of the eye (the iris) or other tissues nearby. It is a rare type of cancer.
UV Index
The UV index is a measurement of how much ultraviolet radiation is reaching a particular place at a given time. UV index forecasts are sometimes given as part of weather reports.

References

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Physician Information References
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Relationship between sun exposure and melanoma risk for tumours in different body sites in a large case-control study in a temperate climate, Eur J Cancer (2010),
doi:10.1016/j.ejca.2010.10.008, in press.
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Cutaneous malignant melanoma in women is uncommonly associated with a family history of melanoma in first-degree relatives: a case control study.
Melanoma Research, 1996. 6: p. 435-440.
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3. Aitken, J.F., D.L. Duffy, A. Green, et al.,
Heterogeneity of melanoma risk in families of melanoma patients.
American Journal of Epidemiology, 1994. 140(11): p. 961-973.
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4. Bataille, V., R. Hiles, and J. Newton Bishop,
Retinoblastoma, melanoma and the atypical mole syndrome.
British Journal of Dermatology, 1995. 60: p. 622-626.
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5. Traboulsi, E.I., L.E. Zimmerman, and H.J. Manz,
Cutaneous Malignant Melanoma in Survivors of Heritable Retinoblastoma.
Arch Ophthalmology, 1988. 106: p. 1059-1061.
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6. McKusick, V.,
nline Mendelian Inheritance in Man.
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7. Li, F.P. and J.F. Fraumeni Jr,
Soft-Tissue Sarcomas, Breast Cancer, and other Neoplasms. A Familial Syndrome? Ann.
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8. Santibanez-Koref, M.F., J.M. Birch, A.L. Hartley, et al.,
p53 germline mutations in Li-Fraumeni syndrome.
Lancet, 1991. 338: p. 1490-1491.
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9. Travis, L.B., R.E. Curtis, H. Storm, et al.,
Risk of second malignant neoplasms among long-term survivors of testicular cancer.
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10. Paunu, N., E. Pukkala, P. Laippala, et al.,
Cancer incidence in families with multiple glioma patients.
Int J Cancer, 2002. 97(6): p. 819-22.
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11. Hisada, M., R.J. Biggar, M.H. Greene, et al.,
Solid tumors after chronic lymphocytic leukemia.
Blood, 2001. 98(6): p. 1979-81.
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12. Harland, M, R. Meloni, N. Gruis, et al.,
Germline mutations of the CDKN2 gene in UK melanoma families, in Human Molecular Genetics.
1997. p. 2061-2067.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=9328469
13. Harland, M., E.A. Holland, P. Ghiorzo, et al.,
Mutation screening of the CDKN2A promoter in melanoma families.
Genes Chromosomes Cancer, 2000. 28(1): p. 45-57.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10738302
14. Harland, M., S. Mistry, D.T. Bishop, et al.,
A deep intronic mutation in CDKN2A is associated with disease in a subset of melanoma pedigrees.
Hum Mol Genet, 2001. 10(23): p. 2679-86.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11726555
15. Newton Bishop, J.A., M. Harland, D.C. Bennett, et al.,
Mutation testing in melanoma families: INK4A, CDK4 and INK4D.
Br J Cancer, 1999. 80(1-2): p. 295-300.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10390011
16. Bergman, W., P. Watson, J. de Jong, et al.,
Systemic cancer and the FAMMM syndrome.
British Journal of Cancer, 1990. 61: p. 932-936.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=2372499
17. Lynch, H.T. and R.M. Fusaro,
Pancreatic cancer and the familial atypical multiple mole melanoma (FAMMM) syndrome.
Pancreas, 1991. 6(2): p. 127-131.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=1886881
18. Zuo, L., J. Weger, Q. Yang, et al.,
Germline mutations in the p16INK4a binding domain of CDK4 in familial melanoma.
Nature Genetics, 1996. 12(1): p. 97-99.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8528263
19. Randerson-Moor, J.A., M. Harland, S. Williams, et al.,
A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family.
Hum Mol Genet, 2001. 10(1): p. 55-62.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=111367140
20. Valverde, P., E. Healy, I. Jackson, et al.,
Variants of the melanocyte stimulating hormone receptor gene are associated with red hair and fair skin in humans.
Nature Gentics, 1995. 11: p. 328-330.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=7581459
21. Bastiaens, M., J. ter Huurne, N. Gruis, et al.,
The melanocortin-1-receptor gene is the major freckle gene.
Hum Mol Genet, 2001. 10(16): p. 1701-8.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11487574
22. Valverde, P., E. Healy, S. Sikkink, et al.,
The Asp84Glu variant of the melanocortin 1 receptor (MC1R) is associated with melanoma.
Human Molec Genet, 1996. 5(10): p. 1663-1666.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=8894704
23. Palmer, J.S., D.L. Duffy, N.F. Box, et al.,
Melanocortin-1 receptor polymorphisms and risk of melanoma: is the association explained solely by pigmentation phenotype?
Am J Hum Genet, 2000. 66(1): p. 176-86.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10631149
24. Winsey, S.L., N.A. Haldar, H.P. Marsh, et al.,
A variant within the DNA repair gene XRCC3 is associated with the development of melanoma skin cancer.
Cancer Res, 2000. 60(20): p. 5612-6.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11059748
25. Shahbazi, M., V. Pravica, N. Nasreen, et al.,
Association between functional polymorphism in EGF gene and malignant melanoma.
Lancet, 2002. 359(9304): p. 397-401.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=11844511
26. Clark, W.H., Jr., R.R. Reimer, M. Greene, et al.,
Origin of familial malignant melanomas from heritable melanocytic lesions. 'The B-K mole syndrome'.
Arch Dermatol, 1978. 114(5): p. 732-8.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=646394
27. Newton Bishop, J., M. Harland, R. Wachsmuth, et al.,
Genotype/phenotype and penetrance studies in melanoma families with germline CDKN2A mutations.
J Invest Dermatol, 2000. 114: p. 28-33.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=10620111
28. Bishop, D.T., F. Demenais, A.M. Goldstein, et al.,
Geographical variation in the penetrance of CDKN2A mutations for melanoma.
J Natl Cancer Inst, 2002. 94(12): p. 894-903.
www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=pubmed&dopt=Abstract&list_uids=12072543
Consortium Information References
1. Harland, M., et al.,
Mutation screening of the CDKN2A promoter in melanoma families.
Genes Chromosomes Cancer, 2000. 28(1): p. 45-57.
2. Pollock PM, et al.,
Mutation analysis of the CDKN2A promoter in Australian melanoma families.
Genes Chromosomes Cancer. 2001 32(1):p 89-94.
3. Liu, L., et al.,
Mutation of the CDKN2A5'UTR creates an aberrant initiation codon and predisposes to melanoma.
Nature Genetics, 1999. 21: p. 1-5.
4. Harland, M., et al.,
A deep intronic mutation in CDKN2A is associated with disease in a subset of melanoma pedigrees.
Hum Mol Genet, 2001. 10(23): p. 2679-86.
5. Randerson-Moor, J.A., et al.,
A germline deletion of p14(ARF) but not CDKN2A in a melanoma-neural system tumour syndrome family.
Hum Mol Genet, 2001. 10(1): p. 55-62.
6. Rizos, H., et al.,
A melanoma-associated germline mutation in exon 1beta inactivates p14ARF.
Oncogene, 2001. 20(39): p. 5543-7.
7. Gillanders, E., et al.,
Localization of a novel melanoma susceptibility locus to 1p22.
Am J Hum Genet, 2003. 73(2): p. 301-13.
8. Bishop, D.T., et al.,
Geographical variation in the penetrance of CDKN2A mutations for melanoma.
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